Open AccessOmeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity
Author(s) -
Lianmei Wang,
Hongbing Zhang,
Chunying Li,
Yan Yi,
Jing Liu,
Yong Zhao,
Jingzhuo Tian,
Yushi Zhang,
Xiaolu Wei,
Yue Gao,
Aihua Liang
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0164215
Subject(s) - nephrotoxicity , aristolochic acid , pharmacology , omeprazole , chemistry , aristolochia , kidney , medicine , biology , traditional medicine , genetics
Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells (HKCs). HKCs with ectopic CYP 1A1 expression were more tolerant to AA than the control cells. Therefore, OM may alleviate AMK-mediated acute nephrotoxicity through induction of CYP 1A1. We suggest that the coadministration of OM might be beneficial for reducing of AA-induced nephrotoxicity.