Open AccessThe Significance of Serum HER2 Levels at Diagnosis on Intrinsic Subtype-Specific Outcome of Operable Breast Cancer Patients
Author(s) -
Moo Hyun Lee,
SoYoun Jung,
Sanggil Kang,
Eun Jin Song,
In Hae Park,
SunYoung Kong,
Younggoo Kwon,
Keun Seok Lee,
Hyejin Kang
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0163370
Subject(s) - medicine , breast cancer , oncology , stage (stratigraphy) , mastectomy , immunohistochemistry , chemotherapy , cancer , trastuzumab , gastroenterology , biology , paleontology
Purpose This study evaluated the association of serum HER2 (sHER2) levels at diagnosis with clinicopathologic parameters and disease free survival (DFS) in operable breast cancer patients according to intrinsic subtype. Methods The sHER2 levels were measured using a chemiluminescence immunoassay. The HER2 status in all tumor tissues was determined by immunohistochemistry, and confirmed in equivocal cases by fluorescence in situ. Results There were 436 consecutive stage I-III breast cancer patients with sHER2 result at diagnosis between Nov 2004 and Dec 2011. High sHER2 levels (≥ 15 ng/ml) were reported in 52 patients (11.9%) and HER2 overexpression in tumor tissue was observed in 111 patients (25.5%). High sHER2 levels were associated significantly with advanced stage ( P < 0.001), mastectomy ( P = 0.012), neoadjuvant chemotherapy ( P < 0.001), anti-HER2 therapy ( P < 0.001) and hormone therapy ( P = 0.022). The patients with high sHER2 levels had a worse DFS ( P < 0.001). In multivariate analysis, high sHER2 levels were associated significantly with worse DFS (HR = 2.25, 95% CI 1.27–3.99, P = 0.005). High sHER2 levels were associated with worse DFS in the HR+/HER2-, HR+/HER2+ and HR-/HER2+ subtypes ( P = 0.043, 0.003 and 0.041, respectively). Conclusions These results show that the sHER2 level at diagnosis is a useful prognostic factor in patients with operable breast cancer, especially in the HR+/HER2-, HR+/HER2+ and HR-/HER2+ subtypes.