CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum | Zendy

Carolina Salomão Lopes | Zendy; Nada Daifalla | Zendy; Bikul Das | Zendy; Valdo Dias da Silva | Zendy; Antonio CamposNeto | Zendy

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CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum

Author(s) -

Carolina Salomão Lopes,

Nada Daifalla,

Bikul Das,

Valdo Dias da Silva,

Antonio CamposNeto

Publication year - 2016

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0162927

Subject(s) - leishmania infantum , mesenchymal stem cell , visceral leishmaniasis , leishmania donovani , leishmaniasis , leishmania , biology , bone marrow , immunology , virology , parasite hosting , microbiology and biotechnology , world wide web , computer science

Visceral leishmaniasis (VL) is a serious and fatal disease. Therapeutic drugs are toxic and non-sterilizing. The etiological agents Leishmania infantum and Leishmania donovani cause active and asymptomatic diseases. Effective drugs to treat VL exist but unfortunately, post-treatment relapses are common. Little is known why drugs are non-sterilizing or how these intracellular pathogens can escape treatment. Here, using a murine model of VL we found that CD271+/Sca1+ bone marrow mesenchymal stem cells (BM-MSCs) are readily infected in vitro and in vivo by L . infantum . Because BM-MSCs express potent drug efflux pumps, e.g., ABCG2 it is possible that this unique intracellular infectious niche could allow L . infantum to escape anti-parasite drugs.

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