Open AccessA High-Resolution Magic Angle Spinning NMR Study of the Enantiodiscrimination of 3,4-Methylenedioxymethamphetamine (MDMA) by an Immobilized Polysaccharide-Based Chiral Phase
Author(s) -
Juliana Cristina Barreiro,
Márcio W. Paixão,
Tiago C. Lourenço,
Quézia B. Cass,
Tiago Venâncio
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0162892
Subject(s) - enantiomer , chemistry , magic angle spinning , moiety , chiral resolution , nuclear magnetic resonance spectroscopy , chirality (physics) , proton nmr , solid state nuclear magnetic resonance , chromatography , stereochemistry , nuclear magnetic resonance , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
This paper reports the investigation of the chiral interaction between 3,4-methylenedioxy-methamphetamine (MDMA) enantiomers and an immobilized polysaccharide-based chiral phase. For that, suspended-state high-resolution magic angle spinning nuclear magnetic resonance spectroscopy ( 1 H HR-MAS NMR) was used. 1 H HR-MAS longitudinal relaxation time and Saturation Transfer Difference (STD NMR) titration experiments were carried out yielding information at the molecular level of the transient diastereoisomeric complexes of MDMA enantiomers and the chiral stationary phase. The interaction of the enantiomers takes place through the aromatic moiety of MDMA and the aromatic group of the chiral selector by π-π stacking for both enantiomers; however, a stronger interaction was observed for the ( R )-enantiomer, which is the second one to elute at the chromatographic conditions.