Open AccessAdherence of Staphylococcus aureus to Dyneema Purity® Patches and to Clinically Used Cardiovascular Prostheses
Author(s) -
Amir Basir,
Paul F. Gründeman,
Frans L. Moll,
Joost A. van Herwaarden,
Gérard Pasterkamp,
Reindert Nijland
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0162216
Subject(s) - staphylococcus aureus , medicine , prosthesis , biomedical engineering , surgery , bacteria , biology , genetics
Various materials that are used for vascular and heart valve prostheses carry drawbacks: some require anticoagulant drugs or have moderate durability; others are not suitable for endovascular treatment. These prostheses are associated with bacterial infections. A material potentially suitable for prostheses is Dyneema Purity ® , made of ultra—high-molecular-weight polyethylene. Dyneema Purity ® fibers are very thin, flexible, resistant to fatigue and abrasion, and have high strength. S . aureus adherence to Dyneema Purity ® was tested and compared with currently used cardiovascular prostheses. We compared adhesion of S . aureus to Dyneema Purity ® (1 membrane-based and 1 yarn-composed patch) with 5 clinically used yarn-composed polyester and membrane-based expanded polytetrafluoroethylene patches. Patches were contaminated with S . aureus bacteria and bacterial adherence was quantified. S . aureus adherence was also visualized in flow conditions. Overall, bacterial adherence was higher on yarn-composed prosthesis materials, with a rough surface, than on the membrane-based materials, with a smooth surface. Adherence to Dyneema Purity ® materials was non-inferior to the currently used materials. Therefore, patches of Dyneema Purity ® might be attractive for use in cardiovascular applications such as catheter-based heart valves and endovascular prostheses by their good mechanical properties combined with their noninferiority regarding bacterial adhesion.