Open AccessAssessment of Cortical Dysfunction in Patients with Intermittent Exotropia: An fMRI Study
Author(s) -
Qian Li,
Junxing Bai,
Junran Zhang,
Qiyong Gong,
Longqian Liu
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0160806
Subject(s) - superior parietal lobule , functional magnetic resonance imaging , inferior parietal lobule , neuroscience , magnetic resonance imaging , exotropia , medicine , intermittent exotropia , parietal lobe , superior temporal gyrus , middle temporal gyrus , gyrus , anatomy , psychology , strabismus , radiology
Neural imaging studies have found the connection between strabismus and brain cortex. However, the pathological mechanisms of intermittent exotropia are still not fully understood. In the present study, changes of binocular fusion related cortices in intermittent exotropia were investigated with blood oxygen level dependent functional magnetic resonance imaging. Activated cortices induced by fusion stimulus were found to be distributed in several regions such as bilateral middle occipital gyrus, bilateral middle temporal gyrus, left superior parietal lobule and so on. Compared with normal subjects, the increased activation intensity was observed in bilateral superior parietal lobule and inferior parietal lobule in subjects with intermittent exotropia. These findings indicate that binocular fusion involves a complicated brain network including several regions. And cortical activities of bilateral superior parietal lobule and inferior parietal lobule compensate for the binocular fusion dysfunction in intermittent exotropia.