Open AccessDiffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles
Author(s) -
E. K. Lenzi,
Andressa Novatski,
Paulo Vítor Farago,
Martinha Antunes Almeida,
Sônia Faria Zawadzki,
R. Menechini Neto
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0157662
Subject(s) - caprolactone , diffusion , anomalous diffusion , thermodynamics , diffusion equation , materials science , chemistry , drug delivery , chemical engineering , chromatography , polymer , nanotechnology , polymerization , composite material , physics , knowledge management , innovation diffusion , economy , computer science , engineering , economics , service (business)
We present a generalmodel based on fractional diffusion equation coupled with a kinetic equation through the boundary condition. It covers several scenarios that may be characterized by usual or anomalous diffusion or present relaxation processes on the surface with non-Debye characteristics. A particular case of this model is used to investigate the experimental data obtained from the drug release of the capsaicinoids-loaded Poly (ε-caprolactone) microparticles. These considerations lead us to a good agreement with experimental data and to the conjecture that the burst effect, i.e., an initial large bolus of drug is released before the release rate reaches a stable profile, may be related to an anomalous diffusion manifested by the system.