Open AccessEffect of Surface Modifications of Ti40Zr10Cu38Pd12 Bulk Metallic Glass and Ti-6Al-4V Alloy on Human Osteoblasts In Vitro Biocompatibility
Author(s) -
Andreu Blanquer,
Anna Hynowska,
Carme Nogués,
Elena Ibáñez,
Jordi Sort,
María Dolors Baró,
Berna Özkale,
Salvador Pané,
Eva Pellicer,
Leonardo Barrios
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0156644
Subject(s) - biocompatibility , materials science , corrosion , alloy , amorphous metal , adhesion , surface modification , nanotechnology , biomedical engineering , metallurgy , composite material , chemical engineering , medicine , engineering
The use of biocompatible materials, including bulk metallic glasses (BMGs), for tissue regeneration and transplantation is increasing. The good mechanical and corrosion properties of Ti 40 Zr 10 Cu 38 Pd 12 BMG and its previously described biocompatibility makes it a potential candidate for medical applications. However, it is known that surface properties like topography might play an important role in regulating cell adhesion, proliferation and differentiation. Thus, in the present study, Ti 40 Zr 10 Cu 38 Pd 12 BMG and Ti6-Al-4V alloy were surface-modified electrochemically (nanomesh) or physically (microscratched) to investigate the effect of material topography on human osteoblasts cells (Saos-2) adhesion, proliferation and differentiation. For comparative purposes, the effect of mirror-like polished surfaces was also studied. Electrochemical treatments led to a highly interconnected hierarchical porous structure rich in oxides, which have been described to improve corrosion resistance, whereas microscratched surfaces showed a groove pattern with parallel trenches. Cell viability was higher than 96% for the three topographies tested and for both alloy compositions. In all cases, cells were able to adhere, proliferate and differentiate on the alloys, hence indicating that surface topography plays a minor role on these processes, although a clear cell orientation was observed on microscratched surfaces. Overall, our results provide further evidence that Ti 40 Zr 10 Cu 38 Pd 12 BMG is an excellent candidate, in the present two topographies, for bone repair purposes.