Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis | Zendy

Jingjing Li | Zendy; Kan Chen | Zendy; Sainan Li | Zendy; Tong Liu | Zendy; Fan Wang | Zendy; Yujing Xia | Zendy; Jie Lu | Zendy; Yingqun Zhou | Zendy; Chuanyong Guo | Zendy

Open Access

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis

Author(s) -

Jingjing Li,

Kan Chen,

Sainan Li,

Tong Liu,

Fan Wang,

Yujing Xia,

Jie Lu,

Yingqun Zhou,

Chuanyong Guo

Publication year - 2016

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0152570

Subject(s) - fucoidan , fucus vesiculosus , apoptosis , liver injury , tumor necrosis factor alpha , tradd , concanavalin a , microbiology and biotechnology , cancer research , biology , chemistry , pharmacology , immunology , programmed cell death , biochemistry , botany , polysaccharide , death domain , in vitro , algae

This study aimed to explore the effects of fucoidan from Fucus vesiculosus on concanavalin A (ConA)-induced acute liver injury in mice. Pretreatment with fucoidan protected liver function indicated by ALT, AST and histopathological changes by suppressing inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). In addition, intrinsic and extrinsic apoptosis mediated by Bax, Bid, Bcl-2, Bcl-xL and Caspase 3, 8, and 9 were inhibited by fucoidan and the action was associated with the TRADD/TRAF2 and JAK2/STAT1 signal pathways. Our results demonstrated that fucoidan from Fucus vesiculosus alleviated ConA-induced acute liver injury via the inhibition of intrinsic and extrinsic apoptosis mediated by the TRADD/TRAF2 and JAK2/STAT1 pathways which were activated by TNF-α and IFN-γ. These findings could provide a potential powerful therapy for T cell-related hepatitis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research