Open AccessRBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2
Author(s) -
Xiaoming Wang,
Minran Zhou,
Yue Fu,
Ting Sun,
Jin Chen,
Xue-Mei Qin,
Yuan Yu,
Jihui Jia,
Chunyan Chen
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0152142
Subject(s) - gene knockdown , demethylase , apoptosis , cancer research , retinoblastoma , pathogenesis , regulator , downregulation and upregulation , lymphoblastic leukemia , leukemia , histone , disease , biology , medicine , gene , genetics
Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the histone demethylase retinoblastoma binding protein-2 (RBP2) was overexpressed in both on-going and relapse cases of adult ALL, which revealed that RBP2 overexpression was not only involved in the pathogenesis of ALL but that its overexpression might also be related to relapse of the disease. RBP2 knockdown induced apoptosis and attenuated leukemic cell viability. Our results demonstrated that BCL2 is a novel target of RBP2 and supported the notion of RBP2 being a regulator of BCL2 expression via directly binding to its promoter. As the role of RBP2 in regulating apoptosis was confirmed, RBP2 overexpression and activation of BCL2 might play important roles in ALL development and progression.