Open AccessLong Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer
Author(s) -
Xiaoli Wu,
Xixi He,
Shi Li,
Xiaoqun Xu,
Xiangjian Chen,
Hua Zhu
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0151287
Subject(s) - long non coding rna , biology , colorectal cancer , transcriptome , rna , gene , cancer research , cd44 , microrna , decoy , non coding rna , human genome , gene expression , genome , genetics , cancer , cell , receptor
In addition to protein-coding genes, the human genome makes a large amount of noncoding RNAs. Long non-coding RNAs (lncRNAs) have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. In recent years, lncRNAs have been considered to be the key regulators of tumor behavior. In this study, based on previous research, we investigated the expression and biological role of a newly identified cancer-related lncRNA, lncRNA-uc002kmd . 1 . We analyzed the relationship between lncRNA-uc002kmd . 1 and colorectal cancer (CRC) in a total 45 CRC and paired adjacent, non-tumor tissue samples. We found that lncRNA-uc002kmd . 1 expression was usually highly expressed in carcinoma compared with the tissue adjacent to the carcinoma. Through a series of experiments, the results showed that lncRNA-uc002kmd . 1 regulates CD44 as a molecular decoy for miR211-3p. Our data indicated that the overexpression of lncRNA-uc002kmd . 1 enhanced cell proliferation in CRC.