Open AccessSteroidal Saponins from the Rhizomes of Aspidistra typica
Author(s) -
Cui Jiang,
Li Kang,
Yang Zhao,
Jian Zhao,
Zhang Jie,
Xu Pang,
He Shui Yu,
De Xian Jia,
Chao Liu,
Li Yan Yu,
Péter Bai
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0150595
Subject(s) - rhizome , saponin , chemistry , glycoside , stereochemistry , liliaceae , botany , biology , medicine , alternative medicine , pathology
Eleven new furostanol saponins, typaspidosides B-L ( 1 – 11 ), one new spirostanol saponin, typaspidoside M ( 12 ), and five known spirostanol saponins, 25 S -atropuroside ( 13 ), neoaspidistrin ( 14 ), (25 S )-pratioside D 1 ( 15 ), 25 S -aspidistrin ( 16 ) and 25 S -neosibiricoside ( 17 ) were isolated from the rhizomes of Aspidistra typica Baill. The structures of the new compounds were established using 1D and 2D NMR ( 1 H- 1 H COSY, HMQC, HMBC and ROESY) spectroscopy, high resolution mass spectrometry, and chemical methods. The aglycones of 1 – 3 (unusual furostanol saponins with opened E ring type), 9 and 10 (the methoxyl substituent at C-23 position) were found, identified from natural products for the first time. Moreover, the anti-HIV activities of the isolated steroidal glycosides were assessed, and compounds 13 , 14 , 16 and 17 exhibited high active against HIV-1.