Open AccessRespiratory Viruses Associated Hospitalization among Children Aged <5 Years in Bangladesh: 2010-2014
Author(s) -
Nusrat Homaira,
Stephen P. Luby,
Kamal Hossain,
Kamrul Islam,
Makhdum Ahmed,
Mustafizur Rahman,
Ziaur Rahman,
Repon C. Paul,
Mejbah Bhuiyan,
W. Abdullah Brooks,
Badrul Munir Sohel,
Kajal Chandra Banik,
Marc Alain Widdowson,
Melisa J. Willby,
Mahmudur Rahman,
Joseph S. Bresee,
Katharine Sturm Ramirez,
Eduardo AzzizBaumgartner
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0147982
Subject(s) - medicine , human metapneumovirus , rhinovirus , incidence (geometry) , pediatrics , respiratory system , population , respiratory tract infections , metapneumovirus , human parainfluenza virus , epidemiology , environmental health , physics , optics
Background We combined hospital-based surveillance and health utilization survey data to estimate the incidence of respiratory viral infections associated hospitalization among children aged < 5 years in Bangladesh. Methods Surveillance physicians collected respiratory specimens from children aged <5 years hospitalized with respiratory illness and residing in the primary hospital catchment areas. We tested respiratory specimens for respiratory syncytial virus, parainfluenza viruses, human metapneumovirus, influenza, adenovirus and rhinoviruses using rRT-PCR. During 2013, we conducted a health utilization survey in the primary catchment areas of the hospitals to determine the proportion of all hospitalizations for respiratory illness among children aged <5 years at the surveillance hospitals during the preceding 12 months. We estimated the respiratory virus-specific incidence of hospitalization by dividing the estimated number of hospitalized children with a laboratory confirmed infection with a respiratory virus by the population aged <5 years of the catchment areas and adjusted for the proportion of children who were hospitalized at the surveillance hospitals. Results We estimated that the annual incidence per 1000 children (95% CI) of all cause associated respiratory hospitalization was 11.5 (10–12). The incidences per 1000 children (95% CI) per year for respiratory syncytial virus, parainfluenza, adenovirus, human metapneumovirus and influenza infections were 3(2–3), 0.5(0.4–0.8), 0.4 (0.3–0.6), 0.4 (0.3–0.6), and 0.4 (0.3–0.6) respectively. The incidences per 1000 children (95%CI) of rhinovirus-associated infections among hospitalized children were 5 (3–7), 2 (1–3), 1 (0.6–2), and 3 (2–4) in 2010, 2011, 2012 and 2013, respectively. Conclusion Our data suggest that respiratory viruses are associated with a substantial burden of hospitalization in children aged <5 years in Bangladesh.