Open AccessRapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding
Author(s) -
Susan Morrison,
Grace JohnStewart,
John J. Egessa,
Sezi Mubezi,
Sylvia Kusemererwa,
Dennis K Bii,
Nulu Bulya,
Francis Mugume,
James D. Campbell,
Jonathan Wangisi,
Elizabeth A. Bukusi,
Connie Celum,
Jared M. Baeten,
Partners PrEP Study Team
Publication year - 2015
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0140773
Subject(s) - breastfeeding , medicine , pregnancy , antiretroviral therapy , human immunodeficiency virus (hiv) , obstetrics , clinical trial , breast feeding , viral load , pediatrics , immunology , genetics , biology
During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.