Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity | Zendy

Dawid Lewandowski | Zendy; Marta Lewandowska | Zendy; Piotr Ruszkowski | Zendy; Anita Pińska | Zendy; Grzegorz Schroeder | Zendy

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Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity

Author(s) -

Dawid Lewandowski,

Marta Lewandowska,

Piotr Ruszkowski,

Anita Pińska,

Grzegorz Schroeder

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0126251

Subject(s) - hela , mesoporous silica , zidovudine , cytotoxic t cell , cytotoxicity , chemistry , conjugated system , covalent bond , silicon dioxide , combinatorial chemistry , cell culture , nuclear chemistry , mesoporous material , biochemistry , organic chemistry , cell , human immunodeficiency virus (hiv) , materials science , biology , virology , in vitro , polymer , catalysis , genetics , viral disease , metallurgy

Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).

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