Open AccessImmobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
Author(s) -
Dawid Lewandowski,
Marta Lewandowska,
Piotr Ruszkowski,
Anita Pińska,
Grzegorz Schroeder
Publication year - 2015
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0126251
Subject(s) - hela , mesoporous silica , zidovudine , cytotoxic t cell , cytotoxicity , chemistry , conjugated system , covalent bond , silicon dioxide , combinatorial chemistry , cell culture , nuclear chemistry , mesoporous material , biochemistry , organic chemistry , cell , human immunodeficiency virus (hiv) , materials science , biology , virology , in vitro , polymer , catalysis , genetics , viral disease , metallurgy
Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).