The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study | Zendy

Amos Gdalyahu | Zendy; María T. Lázaro | Zendy; Olga Peñagarikano | Zendy; Peyman Golshani | Zendy; Joshua T. Trachtenberg | Zendy; Daniel H. Gescwind | Zendy

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The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study

Author(s) -

Amos Gdalyahu,

María T. Lázaro,

Olga Peñagarikano,

Peyman Golshani,

Joshua T. Trachtenberg,

Daniel H. Gescwind

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0125633

Subject(s) - dendritic spine , autism , neuroscience , biology , spine (molecular biology) , in vivo , microbiology and biotechnology , psychology , genetics , developmental psychology , hippocampal formation

The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process. Indeed, we found that new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry.

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