Open AccessAssociations of ABHD2 Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population
Author(s) -
Li Liu,
Xiangshun Li,
Rui Yuan,
Honghong Zhang,
Qiang Lü,
Jingling Shen,
Shoude Jin
Publication year - 2015
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0123929
Subject(s) - copd , medicine , vital capacity , genotype , pulmonary disease , population , bronchodilator , gene , lung , asthma , biology , genetics , lung function , environmental health , diffusing capacity
The human α/β hydrolase domain-containing protein 2 gene ( ABHD2 ) plays a critical role in pulmonary emphysema, a major subset of the clinical entity known as chronic obstructive pulmonary disease (COPD). Here, we evaluated genetic variation in the ABHD2 gene in a Chinese Han population of 286 COPD patients and 326 control subjects. The rs12442260 CT/CC genotype was associated with COPD ( P < 0.001) under a dominant model. In the former-smoker group, the rs12442260 TT genotype was associated with a decreased risk of developing COPD after adjusting for age, gender and pack-years ( P = 0.012). Rs12442260 was also associated with pre-FEV1 (the predicted bronchodilator forced expiratory volume in the first second) in controls ( P = 0.027), but with FEV1/ forced vital capacity (FVC) ratios only in COPD patients ( P = 0.012) under a dominant model. Results from the current study suggest that ABHD2 gene polymorphisms contribute to COPD susceptibility in the Chinese Han population.