RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development | Zendy

Thorsten Pfirrmann | Zendy; Pablo VillavicencioLorini | Zendy; Abinash K. Subudhi | Zendy; Ruth Menssen | Zendy; Dieter H. Wolf | Zendy; Thomas Hollemann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development

Author(s) -

Thorsten Pfirrmann,

Pablo VillavicencioLorini,

Abinash K. Subudhi,

Ruth Menssen,

Dieter H. Wolf,

Thomas Hollemann

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0120342

Subject(s) - ubiquitin ligase , xenopus , ubiquitin , biology , microbiology and biotechnology , dna ligase , forebrain , ectoderm , ubiquitin protein ligases , embryogenesis , biochemistry , embryo , neuroscience , gene , central nervous system

In Saccharomyces cerevisiae the Gid-complex functions as an ubiquitin-ligase complex that regulates the metabolic switch between glycolysis and gluconeogenesis. In higher organisms six conserved Gid proteins form the CTLH protein-complex with unknown function. Here we show that Rmnd5, the Gid2 orthologue from Xenopus laevis, is an ubiquitin-ligase embedded in a high molecular weight complex. Expression of rmnd5 is strongest in neuronal ectoderm, prospective brain, eyes and ciliated cells of the skin and its suppression results in malformations of the fore- and midbrain. We therefore suggest that Xenopus laevis Rmnd5, as a subunit of the CTLH complex, is a ubiquitin-ligase targeting an unknown factor for polyubiquitination and subsequent proteasomal degradation for proper fore- and midbrain development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research