Open AccessComplex Interaction of Deferasirox and Pythium insidiosum: Iron-Dependent Attenuation of Growth In Vitro and Immunotherapy-Like Enhancement of Immune Responses In Vivo
Author(s) -
Régis A. Zanette,
Paula Eliete Rodrigues Bitencourt,
Dimitrios P. Kontoyiannis,
Rafael A. Fighera,
Mariana Martins Flores,
Gláucia D. Kommers,
Priscila S. Silva,
Aline Ludwig,
Maria Beatriz Moretto,
Sydney Hartz Alves,
Jânio M. Santurio
Publication year - 2015
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0118932
Subject(s) - deferasirox , pythium , in vivo , in vitro , biology , microbiology and biotechnology , immune system , deferoxamine , deferiprone , immunotherapy , immunology , biochemistry , genetics , thalassemia , horticulture
Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P . insidiosum hyphae in vitro , but that activity is diminished in the presence of exogenous iron. The tissue activity of the proinflammatory enzyme adenosine deaminase and the histological pattern observed in pythiosis lesions of rabbits treated with deferasirox were similar to the ones in animals treated with immunotherapy.