Open AccessModeling the Effect of Intra-Voxel Diffusion of Contrast Agent on the Quantitative Analysis of Dynamic Contrast Enhanced Magnetic Resonance Imaging
Author(s) -
Stephanie L. Barnes,
C. Chad Quarles,
Thomas E. Yankeelov
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0108726
Subject(s) - voxel , magnetic resonance imaging , contrast (vision) , nuclear magnetic resonance , diffusion mri , gadolinium , dynamic contrast , diffusion , dynamic contrast enhanced mri , biomedical engineering , materials science , physics , medicine , radiology , optics , metallurgy , thermodynamics
Quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides estimates of physiologically relevant parameters related to tissue blood flow, vascular permeability, and tissue volume fractions which can then be used for prognostic and diagnostic reasons. However, standard techniques for DCE-MRI analysis ignore intra-voxel diffusion, which may play an important role in contrast agent distribution and voxel signal intensity and, thus, will affect quantification of the aforementioned parameters. To investigate the effect of intra-voxel diffusion on quantitative DCE-MRI, we developed a finite element model of contrast enhancement at the voxel level. For diffusion in the range of that expected for gadolinium chelates in tissue (i.e., 1×10 −4 to 4×10 −4 mm 2 /s), parameterization errors range from −58% to 12% for K trans , −9% to 8% for v e , and −60% to 213% for v p over the range of K trans , v e , v p , and temporal resolutions investigated. Thus the results show that diffusion has a significant effect on parameterization using standard techniques.