Open AccessAnalysis of Lymph Node Metastasis Correlation with Prognosis in Patients with T2 Gastric Cancer
Author(s) -
Xiaowen Liu,
Ziwen Long,
Hong Cai,
Hua Huang,
Yingqiang Shi,
Yag Wang
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0105112
Subject(s) - medicine , pathological , stage (stratigraphy) , univariate analysis , metastasis , cancer , lymph node , gastrectomy , t stage , survival rate , primary tumor , oncology , multivariate analysis , pathology , radiology , biology , paleontology
Purpose To investigate the correlated factors for lymph node metastasis and prognosis for patients with T2 gastric cancer. Methods A total of 442 patients with T2 gastric cancer who underwent gastrectomy from January 1996 to December 2009 were evaluated. The clinicopathological parameters were analyzed for lymph node metastasis and prognosis, including gender, age, tumor size, tumor location, histological type, depth of invasion, vascular tumor emboli, nervous invasion, resection type, and pathological stage. Results The rate of lymph node metastasis was 45.9%. Univariate analysis showed that depth of invasion, tumor size, and vascular tumor emboli were associated with lymph node metastasis. Logistic regression demonstrated that depth of invasion, tumor size, and vascular tumor emboli were independently predictive factors for lymph node metastasis. The 5-year survival rate was 64.0%. Multivariate analysis showed that tumor size, tumor location, resection type, and pathological stage were independent prognostic factors. Based on tumor size, there were significant differences of 5-year survival between small size tumor (<6 cm) and large size tumor (≥6 cm) according to stage IIA ( P = 0.006). Based on tumor location, there were significant differences of 5-year survival among different tumor location according to stage IB. Based on resection type, there were significant differences of overall 5-year survival between curative surgery and palliative surgery according to stage IIB ( P = 0.015) and IIIA ( P = 0.001). Conclusion Depth of invasion, tumor size, and vascular tumor emboli were independently predictive factors for lymph node metastasis. Tumor size, tumor location, resection type, and pathological stage were independent prognostic factors.