Open AccessAssociation of Saccade Duration and Saccade Acceleration/Deceleration Asymmetry during Visually Guided Saccade in Schizophrenia Patients
Author(s) -
Hong Cui,
Xiaohui Liu,
Ke-Yong Wang,
Chunyan Zhu,
Chen Wang,
Xin Xie
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0097308
Subject(s) - saccade , audiology , acceleration , schizophrenia (object oriented programming) , asymmetry , latency (audio) , medicine , psychology , eye movement , physical medicine and rehabilitation , physics , neuroscience , computer science , psychiatry , telecommunications , classical mechanics , quantum mechanics
Objective To examine the difference between schizophrenia patients and normal controls on velocity and acceleration of saccade, by using the basic visually guided saccade (VGS) paradigm. Methods Eighteen schizophrenia outpatients and fourteen normal controls participated in the VGS task. Multiple indicators, including amplitude, duration, velocity, latency, accuracy rate, acceleration, and deceleration were analyzed. Asymmetric acceleration index (AAI) was introduced to describe the difference between peak acceleration and peak deceleration. The correlation coefficient (R AD ) of AAI and duration was computed to examine the difference between schizophrenia patients and normal controls. Results No significant difference between patients and normal controls was found on amplitude, duration, latency, and accuracy rate. However, R AD values of schizophrenia patients were significantly lower than the control group. Conclusion Compared to normal controls, association of saccade duration and saccade acceleration/deceleration asymmetry during visually guided saccade was lower in schizophrenia patients.