Open AccessThe Safety and Treatment Response of Combination Therapy of Radioimmunotherapy and Radiofrequency Ablation for Solid Tumor: A Study In Vivo
Author(s) -
Songyuan Zheng,
HuiXiong Xu,
LeHang Guo,
Linna Liu,
Feng Lu
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0096539
Subject(s) - medicine , radioimmunotherapy , in vivo , radiofrequency ablation , toxicity , nuclear medicine , urology , ablation , surgery , antibody , immunology , microbiology and biotechnology , monoclonal antibody , biology
Objection To investigate the safety and treatment response of radioimmunotherapy (RIT) in combination with radiofrequency ablation (RFA) for the treatment of VX 2 tumor on rabbit. Materials and Methods A total of 36 rabbits bearing VX 2 tumor on the thigh were randomly assigned into 3 groups (group I: 1–2 cm; group II: 2–3 cm; group III: 3–4 cm) and 4 subgroups (A: as control, just puncture the tumor using the RFA electrode without power output; B: RFA alone; C: 131 I-chTNT intratumoral injection alone; D: RFA+ 131 I-chTNT intratumoral injection 3 days later). The variation of blood assay, weight and survival among different groups and subgroups were used to assess the treatment safety. Ultrasound (US) was used to monitor and assess the tumor response after treatment. Results According to the results of the weight and the blood assay among different groups, subgroups, and at two time points (one day before and the 16th day after treatment), no damages to the liver, kidney function and myelosuppression resulting from the treatment were found. No significant differences in survivals among the four subgroups ( p = 0.087) were found. In addition, 131 I-chTNT did not show significant inhibition effect on VX 2 tumor progression according to US measurements. Conclusion 131 I-chTNT intratumoral injection alone or in combination with RFA is relatively safe for rabbit without significant toxicity and shows no significant effect on the survival. The treatment response is not as satisfactory as anticipated.