Open AccessEvaluation of Candidate Nephropathy Susceptibility Genes in a Genome-Wide Association Study of African American Diabetic Kidney Disease
Author(s) -
Nicholette D. Palmer,
Maggie C. Y. Ng,
Pamela J. Hicks,
Poorva Mudgal,
Carl D. Langefeld,
Barry I. Freedman,
Donald W. Bowden
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0088273
Subject(s) - single nucleotide polymorphism , candidate gene , genetics , biology , genome wide association study , kidney disease , genetic association , population , diabetic nephropathy , nephropathy , type 2 diabetes , haplotype , diabetes mellitus , gene , allele , genotype , medicine , endocrinology , kidney , environmental health
Type 2 diabetes (T2D)-associated end-stage kidney disease (ESKD) is a complex disorder resulting from the combined influence of genetic and environmental factors. This study contains a comprehensive genetic analysis of putative nephropathy loci in 965 African American (AA) cases with T2D-ESKD and 1029 AA population-based controls extending prior findings. Analysis was based on 4,341 directly genotyped and imputed single nucleotide polymorphisms (SNPs) in 22 nephropathy candidate genes. After admixture adjustment and correction for multiple comparisons, 37 SNPs across eight loci were significantly associated (1.6E-05