Open AccessThe Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects
Author(s) -
Ryo Jimbo,
Nick Tovar,
Malvin N. Janal,
Ramy Mousa,
Charles Marin,
Doo-Yeol Yoo,
Hellen S. Teixeira,
Rodolfo Bruniera Anchieta,
Estevam A. Bonfante,
Akihiro Konishi,
Katsuhiro Takeda,
Hidemi Kurihara,
Paulo G. Coelho
Publication year - 2014
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0084845
Subject(s) - periodontal fiber , furcation defect , cementum , dental alveolus , hyaluronic acid , dental cementum , molar , periodontium , dentistry , clinical attachment loss , buccal administration , brain derived neurotrophic factor , neurotrophic factors , medicine , cementogenesis , periodontitis , pathology , chemistry , anatomy , receptor , dentin
This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e. , alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.