Open AccessNegative Emotion Regulation in Patients with Posttraumatic Stress Disorder
Author(s) -
Kun-Lin Xiong,
Ye Zhang,
Mingguo Qiu,
Jingna Zhang,
Linqiong Sang,
Li Wang,
Bing Xie,
Jian Wang,
Min Li
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0081957
Subject(s) - functional magnetic resonance imaging , amygdala , insula , psychology , anterior cingulate cortex , putamen , neuroscience , neural correlates of consciousness , negative emotion , posttraumatic stress , inferior parietal lobule , clinical psychology , developmental psychology , cognition
Objective To explore the neural mechanisms of negative emotion regulation in patients with post-traumatic stress disorder (PTSD). Methods Twenty PTSD patients and 20 healthy subjects were recruited. Event-related functional magnetic resonance imaging (fMRI) was used to investigate the modification of emotional responses to negative stimuli. Participants were required to regulate their emotional reactions according to the auditory regulation instructions via headphones, to maintain, enhance or diminish responses to negative stimuli during fMRI scans. Results The PTSD group showed poorer modification performance than the control group when diminishing responses to negative stimuli. On fMRI, the PTSD group showed decreased activation in the inferior frontal cortex, inferior parietal lobule, insula and putamen, and increased activation in posterior cingulate cortex and amygdala during up-regulation of negative emotion. Similar decreased activation regions were found during down-regulation of negative emotion, but no increased activation was found. Conclusion Trauma exposure might impair the ability to down-regulate negative emotion. The present findings will improve our understanding of the neural mechanisms of emotion regulation underlying PTSD.