Open AccessBenign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation
Author(s) -
Nengwang Yu,
Shuai Fu,
Yibao Liu,
Zhihou Fu,
Jie Meng,
Xu Zhang,
Baocheng Wang,
Aimin Zhang
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0081745
Subject(s) - kidney , cancer , cancer cell , medicine , pathology , organ culture , cancer research , renal stem cell , kidney cancer , renal cell carcinoma , biology , chemistry , in vitro , stem cell , microbiology and biotechnology , biochemistry , progenitor cell
The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.