Ubiquitin-Specific Peptidase 5, a Target Molecule of Vialinin A, Is a Key Molecule of TNF-α Production in RBL-2H3 Cells | Zendy

Yasukiyo Yoshioka | Zendy; Yue Qi Ye | Zendy; Kiyoshi Okada | Zendy; Kayoko Taniguchi | Zendy; Ayaka Yoshida | Zendy; Kimio Sugaya | Zendy; Junichi Onose | Zendy; Hiroyuki Koshino | Zendy; Shunya Takahashi | Zendy; Arata Yajima | Zendy; Shunsuke Yajima | Zendy; Naoki Abe | Zendy

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Ubiquitin-Specific Peptidase 5, a Target Molecule of Vialinin A, Is a Key Molecule of TNF-α Production in RBL-2H3 Cells

Author(s) -

Yasukiyo Yoshioka,

Yue Qi Ye,

Kiyoshi Okada,

Kayoko Taniguchi,

Ayaka Yoshida,

Kimio Sugaya,

Junichi Onose,

Hiroyuki Koshino,

Shunya Takahashi,

Arata Yajima,

Shunsuke Yajima,

Naoki Abe

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0080931

Subject(s) - proinflammatory cytokine , deubiquitinating enzyme , tumor necrosis factor alpha , ubiquitin , microbiology and biotechnology , chemistry , gene knockdown , biochemistry , biology , inflammation , gene , immunology

Tumor necrosis factor alpha (TNF-α), a central mediator of the inflammatory response, is released from basophilic cells and other cells in response to a variety of proinflammatory stimuli. Vialinin A is a potent inhibitor of TNF-α production and is released from RBL-2H3 cells. Ubiquitin-specific peptidase 5 (USP5), a deubiquitinating enzyme, was identified as a target molecule of vialinin A and its enzymatic activity was inhibited by vialinin A. Here we report production of TNF-α is decreased in USP5 siRNA-knockdown RBL-2H3 cells, compared with control cells. The finding of the present study strongly suggests that USP5 is one of the essential molecules for the production of TNF-α in RBL-2H3.

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