Open AccessEnterovirus 74 Infection in Children
Author(s) -
Matthew Peacey,
Richard J. Hall,
Jing Wang,
Angela Todd,
Seiha Yen,
Jasmine V.E. Chan-Hyams,
Christy J. Rand,
JoAnn L. Stanton,
Q. Sue Huang
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0076492
Subject(s) - acute flaccid paralysis , enterovirus , poliomyelitis , virology , paralysis , enterovirus infections , poliovirus , genome , whole genome sequencing , flaccid paralysis , biology , medicine , virus , pediatrics , genetics , gene , surgery
Enterovirus 74 (EV74) is a rarely detected viral infection of children. In 2010, EV74 was identified in New Zealand in a 2 year old child with acute flaccid paralysis (AFP) through routine polio AFP surveillance. A further three cases of EV74 were identified in children within six months. These cases are the first report of EV74 in New Zealand. In this study we describe the near complete genome sequence of four EV74 isolates from New Zealand, which shows only limited sequence identity in the non-structural proteins when compared to the other two known EV74 sequences. As is typical of enteroviruses multiple recombination events were evident, particularly in the P2 region and P3 regions. This is the first complete EV74 genome sequenced from a patient with acute flaccid paralysis.