Open AccessAssociation of Renal Biomarkers with 3-Month and 1-Year Outcomes among Critically Ill Acute Stroke Patients
Author(s) -
YingChih Huang,
YiLing Wu,
Ming-Hsueh Lee,
Jiann-Der Lee,
ChihYing Wu,
Huan-Lin Hsu,
Ya-Hui Lin,
Yen-Chu Huang,
WenHung Huang,
Hsu–Huei Weng,
Jen-Tsung Yang,
Meng Lee,
Bruce Ovbiagele
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0072971
Subject(s) - critically ill , medicine , stroke (engine) , intensive care medicine , critical illness , acute kidney injury , mechanical engineering , engineering
Background The comparative relationships of widely recognized biomarkers of renal injury with short-term and long-term outcomes among critically ill acute stroke patients are unknown. We evaluated the impact of baseline albuminuria [urine albumin-creatinine ratio (UACR)≥30 mg/g] or low estimated glomerular filtration rate (eGFR<60 ml/min per 1.73 m 2 ) on stroke patients admitted to the intensive care unit (ICU). Methods We reviewed data on consecutive stroke patients admitted to a hospital ICU in Taiwan from September 2007 to August 2010 and followed-up for 1 year. Baseline UACR was categorized into <30 mg/g (normal), 30–299 mg/g (microalbuminuria), and ≥300 mg/g (macroalbuminuria), while eGFR was divided into ≥60, 45–59, and <45 ml/min per 1.73 m 2 . The outcome measure was death or disability at 3-month and 1-year after stroke onset, assessed by dichotomizing the modified Rankin Scale at 3–6 versus 0–2. Results Of 184 consecutive patients, 153 (83%) met study entry criteria. Mean age was 67.9 years and median admission NIHSS score was 16. Among the renal biomarkers, only macroalbuminuria was associated with poorer 3-month outcome (OR 8.44, 95% CI 1.38 to 51.74, P = 0.021) and 1-year outcome (OR 18.06, 95% CI 2.59 to 125.94, P = 0.003) after adjustment of relevant covariates. When ischemic and hemorrhagic stroke were analyzed separately, macroalbuminuria was associated with poorer 1-year outcome among ischemic (OR 17.10, 95% CI 1.04 to 280.07, P = 0.047) and hemorrhagic stroke patients (OR 1951.57, 95% CI 1.07 to 3561662.85, P = 0.048), respectively, after adjustment of relevant covariates and hematoma volume. Conclusions Presence of macroalbuminuria indicates poor 3-month and 1-year outcomes among critically ill acute stroke patients.