Open AccessInter-Individual and Inter-Strain Variations in Zebrafish Locomotor Ontogeny
Author(s) -
Merlin Lange,
Frederic Neuzeret,
Benoît Fabrèges,
Cynthia Froc,
Sébastien Bedu,
Laure BallyCuif,
William Norton
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0070172
Subject(s) - zebrafish , biology , ontogeny , strain (injury) , repeatability , phenotype , evolutionary biology , neuroscience , anatomy , genetics , statistics , gene , mathematics
Zebrafish exhibit remarkable alterations in behaviour and morphology as they develop from early larval stages to mature adults. In this study we compare the locomotion parameters of six common zebrafish strains from two different laboratories to determine the stability and repeatability of these behaviours. Our results demonstrate large variability in locomotion and fast swim events between strains and between laboratories across time. These data highlight the necessity for careful, strain-specific controls when analysing locomotor phenotypes and open up the possibility of standardising the quantification of zebrafish behaviour at multiple life stages.