Open AccessAssessing Interactions between Common Genetic Variant on 2q35 and Hormone Receptor Status with Breast Cancer Risk: Evidence Based on 26 Studies
Author(s) -
Tao Huang,
Jun Hong,
Wei Lin,
Qungqing Yang,
NI Ke-liang,
Qingyu Wu,
Jie Sun
Publication year - 2013
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0069056
Subject(s) - breast cancer , odds ratio , medicine , hormone receptor , cancer , genome wide association study , ethnic group , oncology , genetics , biology , genotype , single nucleotide polymorphism , gene , sociology , anthropology
Genome-wide association studies have identified 2q35-rs13387042 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 2q35-rs13387042 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 26 studies involving a total of 101,529 cases and 167,363 controls for 2q35-rs13387042 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.14 (95% CI: 1.11–1.16, P<10 −5 ) was found for rs13387042-A variant. Significant results were also observed using dominant (OR = 1.14, 95% CI: 1.12–1.17, P<10 −5 ), recessive (OR = 1.17, 95% CI: 1.13–1.21, P<10 −5 ) and co-dominant genetic model (heterozygous: OR = 1.15, 95% CI: 1.12–1.19, P<10 −5 ; homozygous: OR = 1.20, 95% CI: 1.15–1.24, P<10 −5 ). There was strong evidence of heterogeneity, which largely disappeared after stratification by ethnicity. Significant associations were found in East Asians, and White populations when stratified by ethnicity; while no significant associations were observed in Africans and other ethnic populations. An association was observed for both ER-positive (OR = 1.17, 95% 1.15–1.19; P<10 −5 ) and ER-negative disease (OR = 1.08, 95% CI: 1.04–1.13; P<10 −4 ) and both progesterone receptor (PR)-positive (OR = 1.18, 95% CI: 1.15–1.21; P<10 −5 ) and PR-negative disease (OR = 1.10, 95% CI: 1.05–1.15; P<10 −4 ). In conclusion, this meta-analysis demonstrated that the A allele of 2q35-rs13387042 is a risk factor associated with increased breast cancer susceptibility.