Open AccessGenetic Variations in ADIPOQ Gene Are Associated with Chronic Obstructive Pulmonary Disease
Author(s) -
Yujia Yuan,
Haiou Jiang,
Jiangying Kuang,
Xiaoming Hou,
Yu Feng,
Zhiguang Su
Publication year - 2012
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0050848
Subject(s) - haplotype , single nucleotide polymorphism , adiponectin , copd , allele , genotype , case control study , genetics , population , genetic association , medicine , linkage disequilibrium , genome wide association study , biology , gene , obesity , insulin resistance , environmental health
Background Adiponectin is reported to be related to the development of chronic obstructive pulmonary disease (COPD). Genetic variants in the gene encoding adiponectin ( ADIPOQ ) have been reported to be associated with adiponectin level in several genome–wide linkage and association studies. However, relatively little is known about the effects of ADIPOQ gene variants on COPD susceptibility. We determined the frequencies of single-nucleotide polymorphisms (SNPs) in ADIPOQ in a Chinese Han population and their possible association with COPD susceptibility. Methods We conducted a case–control study of 279 COPD patients and 367 age- and gender-distribution-matched control subjects. Seven tagging SNPs in ADIPOQ , including rs710445, rs16861205, rs822396, rs7627128, rs1501299, rs3821799 and rs1063537 were genotyped by SNaPshot. Association analysis of genotypes/alleles and haplotypes constructed from these loci with COPD was conducted under different genetic models. Results The alleles or genotypes of rs1501299 distributed significantly differently in COPD patients and controls (allele: P = 0.002, OR = 1.43 and 95%CI = 1.14–1.79; genotype: P = 0.008). The allele A at rs1501299 was potentially associated with an increased risk of COPD in all dominant model analysis ( P = 0.009; OR: 1.54; 95%CI: 1.11–2.13), recessive model analyses ( P = 0.015; OR: 1.75; 95% CI: 1.11–2.75) and additive model analyses ( P = 0.003; OR: 2.11; 95% CI: 1.29–3.47). In haplotype analysis, we observed haplotypes CT and GGACCTC had protective effects, while haplotypes AGAACTC, AGGCCTC, GGAACTC, GGACACT and GGGCCTC were significantly associated with the increased risk of COPD. Conclusions We conducted the first investigation of the association between the SNPs in ADIPOQ and COPD risk. Our current findings suggest that ADIPOQ may be a potential risk gene for COPD. Further studies in larger groups are warranted to confirm our results.