Open AccessAssociation between CD14 Gene C-260T Polymorphism and Inflammatory Bowel Disease: A Meta-Analysis
Author(s) -
Zhengting Wang,
Jiajia Hu,
Rong Fan,
Jie Zhou,
Jie Zhong
Publication year - 2012
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0045144
Subject(s) - odds ratio , inflammatory bowel disease , genotype , allele , meta analysis , genetic model , confidence interval , medicine , ulcerative colitis , gastroenterology , crohn's disease , case control study , genetic association , disease , genetics , biology , single nucleotide polymorphism , gene
Background The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis. Methodology/Principal Findings Seventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (CD) cases, and 4004 controls. Data were analyzed using STATA software. Overall, association between C-260T polymorphism and increased UC risk was significant in allelic comparison (odds ratio [OR] = 1.21, 95% confidence interval [CI]: 1.02–1.43; P = 0.027), homozygote model (OR = 1.44, 95% CI: 1.03–2.01; P = 0.033), as well as dominant model (OR = 1.36, 95% CI: 1.06–1.75; P = 0.016). However, there was negative association between this polymorphism and CD risk across all genetic models. Subgroup analyses by ethnicity suggested the risk-conferring profiles of -260T allele and -260 TT genotype with UC in Asians, but not in Caucasians. There was a low probability of publication bias. Conclusions/Significance Expanding previous results of individual studies, our findings demonstrated that CD14 gene C-260T polymorphism might be a promising candidate marker in susceptibility to UC, especially in Asians.