Phosphorylation-Dependent SUMOylation of the Transcription Factor NF-E2 | Zendy

Yee-Fun Su | Zendy; YuChiau Shyu | Zendy; Che-Kun James Shen | Zendy; Jaulang Hwang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Phosphorylation-Dependent SUMOylation of the Transcription Factor NF-E2

Author(s) -

Yee-Fun Su,

YuChiau Shyu,

Che-Kun James Shen,

Jaulang Hwang

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0044608

Subject(s) - sumo protein , phosphorylation , transcription factor , microbiology and biotechnology , activator (genetics) , chemistry , protein kinase a , biology , nf κb , transcription (linguistics) , signal transduction , biochemistry , ubiquitin , gene , linguistics , philosophy

Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP-dependent protein kinase A (PKA). However, the relationship between SUMOylation and phosphorylation in the activation of NF-E2 is unclear. In the present studies, we have demonstrated that PKA enhances NF-E2 SUMOylation in an in vitro system using purified proteins, suggesting a possible mechanism for PKA-dependent activation of the NF-E2 transcription factor through SUMOylation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research