Open AccessTranscriptional Programs Controlling Perinatal Lung Maturation
Author(s) -
Yan Xu,
Yanhua Wang,
Valérie Besnard,
Machiko Ikegami,
Susan E. Wert,
Caleb Heffner,
Stephen A. Murray,
Leah Rae Donahue,
Jeffrey A. Whitsett
Publication year - 2012
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0037046
Subject(s) - biology , lung , microbiology and biotechnology , andrology , immunology , medicine
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6