Transcriptional Programs Controlling Perinatal Lung Maturation | Zendy

Yan Xu | Zendy; Yanhua Wang | Zendy; Valérie Besnard | Zendy; Machiko Ikegami | Zendy; Susan E. Wert | Zendy; Caleb Heffner | Zendy; Stephen A. Murray | Zendy; Leah Rae Donahue | Zendy; Jeffrey A. Whitsett | Zendy

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Transcriptional Programs Controlling Perinatal Lung Maturation

Author(s) -

Yan Xu,

Yanhua Wang,

Valérie Besnard,

Machiko Ikegami,

Susan E. Wert,

Caleb Heffner,

Stephen A. Murray,

Leah Rae Donahue,

Jeffrey A. Whitsett

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0037046

Subject(s) - biology , lung , microbiology and biotechnology , andrology , immunology , medicine

The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6

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