Open AccessLRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
Author(s) -
Yih Ru Wu,
Louis Tan,
Xiaoli Fu,
Chiung Mei Chen,
Wing Lok Au,
Ling Chen,
Yi Chun Chen,
Kumar M. Prakash,
Yifan Zheng,
Guey Jen Lee-Chen,
Yongxiang Zhao,
Jin Sheng Zeng,
Eng King Tan,
Zhong Pei
Publication year - 2012
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0036123
Subject(s) - lrrk2 , risk factor , parkinson's disease , chinese population , cohort , china , medicine , case control study , chinese people , disease , cohort study , demography , genetics , biology , gene , genotype , geography , archaeology , sociology
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.