Open AccessDefining Obesity Cut-Off Points for Migrant South Asians
Author(s) -
Laura J. Gray,
Thomas Yates,
Melanie J. Davies,
Emer M Brady,
David R. Webb,
Naveed Sattar
Publication year - 2011
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0026464
Subject(s) - waist , body mass index , risk factor , obesity , confidence interval , medicine , type 2 diabetes , population , demography , diabetes mellitus , circumference , lipid profile , blood pressure , endocrinology , mathematics , geometry , environmental health , sociology
Background Body mass index (BMI) and waist circumference (WC) are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population. Methods 4688 White Europeans and 1333 South Asians resident in the UK aged 40–75 years inclusive were screened for type 2 diabetes. Principal components analysis was used to derive a glycaemia, lipid, and a blood pressure factor. Regression models for each factor, adjusted for age and stratified by sex, were used to identify BMI and WC cut-off points in South Asians that correspond to those defined for White Europeans. Findings For South Asian males, derived BMI obesity cut-off points equivalent to 30.0 kg/m 2 in White Europeans were 22.6 kg/m 2 (95% Confidence Interval (95% CI) 20.7 kg/m 2 to 24.5 kg/m 2 ) for the glycaemia factor, 26.0 kg/m 2 (95% CI 24.7 kg/m 2 to 27.3 kg/m 2 ) for the lipid factor, and 28.4 kg/m 2 (95% CI 26.5 kg/m 2 to 30.4 kg/m 2 ) for the blood pressure factor. For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm) for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm) for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm) for the blood pressure factor. Lower ethnicity cut-off points were seen for females for both BMI and WC. Conclusions Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans. South Asian ethnicity could be considered as a similar level of risk as obesity (in White Europeans) for the development of type 2 diabetes.