Open AccessAssociations of HLA-DP Variants with Hepatitis B Virus Infection in Southern and Northern Han Chinese Populations: A Multicenter Case-Control Study
Author(s) -
Li Jin,
Da-guo Yang,
Yueqiu He,
Mengyi Wang,
Zirong Wen,
Lifeng Liu,
Jing Yao,
Koichi Matsuda,
Yusuke Nakamura,
Jianan Yu,
Xiaorui Jiang,
Shuzhen Sun,
Qing Liu,
Xiang Jiang,
Qilong Song,
Man Chen,
Hong Yang,
Feng Tang,
Xiaowen Hu,
Jing Wang,
Ying Chang,
Xingxing He,
Yuan Chen,
JuSheng Lin
Publication year - 2011
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0024221
Subject(s) - virology , biology , human leukocyte antigen , virus , multicenter study , hepatitis b virus , medicine , immunology , antigen , randomized controlled trial
Background Human leukocyte antigen DP ( HLA-DP ) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations. Methodology/Principal Findings Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations ( P = 0.021∼3.36×10 −8 at rs2395309; P = 8.37×10 −3 ∼2.68×10 −10 at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population ( P = 8.95×10 −5 at rs2395309; P = 1.64×10 −9 at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression ( P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively). Conclusions Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.