Open AccessStructure Collisions between Interacting Proteins
Author(s) -
Dorothea Emig,
Oliver Sander,
Gabriele Mayr,
Mario Albrecht
Publication year - 2011
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0019581
Subject(s) - protein structure , protein–protein interaction , plasma protein binding , protein data bank , biophysics , computational biology , protein quaternary structure , chemistry , biology , physics , microbiology and biotechnology , biochemistry , protein subunit , gene
Protein-protein interactions take place at defined binding interfaces. One protein may bind two or more proteins at different interfaces at the same time. So far it has been commonly accepted that non-overlapping interfaces allow a given protein to bind other proteins simultaneously while no collisions occur between the binding protein structures. To test this assumption, we performed a comprehensive analysis of structural protein interactions to detect potential collisions. Our results did not indicate cases of biologically relevant collisions in the Protein Data Bank of protein structures. However, we discovered a number of collisions that originate from alternative protein conformations or quaternary structures due to different experimental conditions.