Interactions between Exposure to Environmental Polycyclic Aromatic Hydrocarbons and DNA Repair Gene Polymorphisms on Bulky DNA Adducts in Human Sperm | Zendy

Guixiang Ji | Zendy; Aihua Gu | Zendy; Yong Zhou | Zendy; Xiangguo Shi | Zendy; Yankai Xia | Zendy; Yan Long | Zendy; Ling Song | Zendy; Shoulin Wang | Zendy; Xinru Wang | Zendy

Open Access

Interactions between Exposure to Environmental Polycyclic Aromatic Hydrocarbons and DNA Repair Gene Polymorphisms on Bulky DNA Adducts in Human Sperm

Author(s) -

Guixiang Ji,

Aihua Gu,

Yong Zhou,

Xiangguo Shi,

Yankai Xia,

Yan Long,

Ling Song,

Shoulin Wang,

Xinru Wang

Publication year - 2010

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0013145

Subject(s) - xrcc1 , dna adduct , dna damage , aristolochic acid , nucleotide excision repair , dna repair , ercc1 , biology , microbiology and biotechnology , dna , base excision repair , chemistry , genetics , genotype , single nucleotide polymorphism , gene

Nucleotide excision repair (NER) and base excision repair (BER) are the primary mechanisms for repair of bulky adducts caused by chemical agents, such as PAHs. It is expected that polymorphisms in NER or BER genes may modulate individual susceptibility to PAHs exposure. Here, we evaluate the effects of PAHs exposure and polymorphisms in NER and BER pathway, alone or combined, on polycyclic aromatic hydrocarbon-DNA (PAH-DNA) adducts in human sperm.

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