Open AccessInteractions between Exposure to Environmental Polycyclic Aromatic Hydrocarbons and DNA Repair Gene Polymorphisms on Bulky DNA Adducts in Human Sperm
Author(s) -
Guixiang Ji,
Aihua Gu,
Yong Zhou,
Xiangguo Shi,
Yankai Xia,
Yan Long,
Song Lee,
Shoulin Wang,
Xinru Wang
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0013145
Subject(s) - xrcc1 , dna adduct , dna damage , aristolochic acid , nucleotide excision repair , dna repair , ercc1 , biology , microbiology and biotechnology , dna , base excision repair , chemistry , genetics , genotype , single nucleotide polymorphism , gene
Nucleotide excision repair (NER) and base excision repair (BER) are the primary mechanisms for repair of bulky adducts caused by chemical agents, such as PAHs. It is expected that polymorphisms in NER or BER genes may modulate individual susceptibility to PAHs exposure. Here, we evaluate the effects of PAHs exposure and polymorphisms in NER and BER pathway, alone or combined, on polycyclic aromatic hydrocarbon-DNA (PAH-DNA) adducts in human sperm.