Open AccessSeroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
Author(s) -
Claude Flamand,
Christelle Alves Sarmento,
Antoine Enfissi,
Sarah Bailly,
Emmanuel Beillard,
Mélanie Gaillet,
Céline Michaud,
V Servas,
Nathalie Clément,
Anaïs Perilhou,
Thierry Carage,
Didier Musso,
Jean-François Carod,
Stéphanie Eustache,
Céline Tourbillon,
Elodie Boizon,
Samantha James,
Félix Djossou,
Henrik Salje,
Simon Cauchemez,
Dominique Rousset
Publication year - 2021
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0009945
Subject(s) - seroprevalence , medicine , covid-19 , pandemic , demography , population , cross sectional study , virology , serology , immunology , antibody , environmental health , outbreak , disease , infectious disease (medical specialty) , pathology , sociology
Background While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. Methodology/Principal findings A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. Conclusions/Significance The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana’s young population structure.