Open AccessSerologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia
Author(s) -
Masahiro Kajihara,
Martin Simuunza,
Ngonda Saasa,
George Dautu,
Akina Mori-Kajihara,
Yongjin Qiu,
Ryo Nakao,
Yoshiki Eto,
Hayato Furumoto,
Bernard M. Hang’ombe,
Yasuko Orba,
Hirofumi Sawa,
Edgar Simulundu,
Shuetsu Fukushi,
Shigeru Morikawa,
Masayuki Saijo,
Jiro Arikawa,
Swithine Kabilika,
Mwaka Monze,
Victor Mukonka,
Aaron S. Mweene,
Ayato Takada,
Kumiko Yoshimatsu
Publication year - 2021
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0009452
Subject(s) - tick , virology , biology , crimean–congo hemorrhagic fever , zoonosis , tick borne disease , ixodidae , vector (molecular biology) , hyalomma , genetics , gene , recombinant dna
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts.