Open AccessClinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study
Author(s) -
Rui Huang,
Li Zhu,
Liutang Xue,
Longgen Liu,
Xuebing Yan,
Jian Wang,
Biao Zhang,
Tingting Xu,
Fang Ji,
Yun Zhao,
Juan Cheng,
Yinling Wang,
Huaping Shao,
Shuqin Hong,
Qi Cao,
Chunyang Li,
Xiang Zhao,
Lei Zou,
Dawen Sang,
Haiyan Zhao,
Xinying Guan,
Xiaobing Chen,
Song Chun,
Juan Xia,
Yuxin Chen,
Xiaomin Yan,
Jie Wei,
Chengliang Zhu,
Chao Wu
Publication year - 2020
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0008280
Subject(s) - medicine , interquartile range , odds ratio , intensive care unit , confidence interval , severity of illness , body mass index , retrospective cohort study , covid-19 , diabetes mellitus , disease , pediatrics , infectious disease (medical specialty) , endocrinology
Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0–54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI) ≥ 28 kg/m 2 (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P<0.001) and a known history of type 2 diabetes (OR, 4.326; 95% CI, 1.059 to 17.668; P = 0.041). In this case series in Jiangsu Province, COVID-19 patients had less severe symptoms and had better outcomes than the initial COVID-19 patients in Wuhan. The BMI ≥ 28 kg/m 2 and a known history of type 2 diabetes were independent risk factors of severe illness in patients with COVID-19.