Open AccessSeroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam
Author(s) -
Fang-Lin Kuo,
Truong Huu Khanh,
Wan-Yu Chung,
Nguyễn Thành Hưng,
Shu-Ting Luo,
Wun-Shaing Wayne Chang,
Nhân Lê Thành,
Le Quoc Thinh,
Min-Shi Lee
Publication year - 2020
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0008124
Subject(s) - seroprevalence , vietnamese , neutralizing antibody , foot and mouth disease , virology , antibody , medicine , vaccination , vaccination policy , enterovirus 71 , enterovirus , demography , outbreak , immunology , serology , virus , linguistics , philosophy , sociology
Enterovirus-A71 (EV-A71) cyclically causes hand-foot-mouth disease (HFMD) epidemics in Asian children. An EV-A71 epidemic occurred in Southern Vietnam in 2011, but its scale is not clear. We collected residual sera from non-HFMD Vietnamese inpatients in 2012–2013 to determine seroprevalence of EV-A71 neutralizing antibodies, and measured cross-reactive neutralizing antibody titers against three EV-A71 genogroups. About 23.5% of 1-year-old children in Southern Vietnam has been infected by EV-A71, and the median age of infection was estimated to be 3 years. No significant antigenic variation could be detected among the three EV-A71 genogroups. The high seroprevalence of EV-A71 neutralizing antibody in children living in southern Vietnam indicates the necessity of introducing EV-A71 vaccines in southern Vietnam, particularly for children under 6 months of age. Moreover, it is critical to understand EV-A71 disease burden for formulating national vaccination policy.