Open AccessPathological roles of MRP14 in anemia and splenomegaly during experimental visceral leishmaniasis
Author(s) -
Kanna Ishizuka,
Wataru Fujii,
Natsuho Azuma,
Haruka Mizobuchi,
Ayako Morimoto,
Chizu Sanjoba,
Yoshitsugu Matsumoto,
Yasuyuki Goto
Publication year - 2020
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0008020
Subject(s) - visceral leishmaniasis , medicine , leishmaniasis , immunology , anemia , exacerbation , leishmania donovani , pathogenesis , leishmania major , leishmania , pathology , parasite hosting , world wide web , computer science
Myeloid-related protein 14 (MRP14) belongs to the S100 calcium-binding protein family and is expressed in neutrophils and inflammatory macrophages. Increase in the number of MRP14 + cells or serum level of MRP14 is associated with various diseases such as autoimmune diseases and infectious diseases, suggesting the involvement of the molecule in pathogenesis of those diseases. In this study, to examine the pathological involvement of MRP14 during cutaneous and visceral leishmaniasis, wild-type (WT) and MRP14 knockout (MRP14KO) mice were infected with Leishmania major and L . donovani . Increase in the number of MRP14 + cells at the infection sites in wild-type mice was commonly found in the skin during L . major infection as well as the spleen and liver during L . donovani infection. In contrast, the influence of MRP14 to the pathology seemed different between the two infections. MRP14 depletion exacerbated the lesion development and ulcer formation in L . major infection. On the other hand, the depletion improved anemia and splenomegaly but not hepatomegaly at 24 weeks of L . donovani infection. These results suggest that, distinct from its protective role in CL, MRP14 is involved in exacerbation of some symptoms during VL.