Open AccessAssessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus
Author(s) -
Kaho H. Tisthammer,
Caroline Solis,
Faye Orcales,
Madu Nzerem,
Ryan Winstead,
Weiyan Dong,
Jeffrey B. Joy,
Pleuni S. Pennings
Publication year - 2022
Publication title -
plos genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.587
H-Index - 233
eISSN - 1553-7404
pISSN - 1553-7390
DOI - 10.1371/journal.pgen.1010179
Subject(s) - biology , nonsynonymous substitution , mutation , genetics , mutation rate , genetic fitness , ns5b , genome , fitness landscape , hepatitis c virus , viral evolution , resistance mutation , virus , virology , computational biology , hepacivirus , gene , population , polymerase chain reaction , demography , reverse transcriptase , sociology