Open AccessZika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference
Author(s) -
Katharine Best,
Dan H. Barouch,
Jérémie Guedj,
Ruy M. Ribeiro,
Alan S. Perelson
Publication year - 2021
Publication title -
plos computational biology/plos computational biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.628
H-Index - 182
eISSN - 1553-7358
pISSN - 1553-734X
DOI - 10.1371/journal.pcbi.1008564
Subject(s) - zika virus , innate immune system , immune system , viral interference , biology , virus , virology , viral infection , immunology , viral load , viral replication
Experimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the viral dynamics and immune response is unclear. Here we study a dataset of experimental infection of non-human primates with a range of doses of Zika virus. We develop new models of infection incorporating both an innate immune response and viral interference with that response. We find that such a model explains the data better than models with no interaction between virus and the immune response. We also find that larger inoculum doses lead to faster dynamics of infection, but approximately the same total amount of viral production.