Open AccessA microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
Author(s) -
Dharaminder Singh,
Sudhir P Deosarkar,
Elaine Cadogan,
Vikki Flemington,
Alysha Bray,
Jingwen Zhang,
Ronald S. Reiserer,
David K. Schaffer,
Gregory B Gerken,
Clayton M. Britt,
Erik M. Werner,
Francis D. Gibbons,
Tomasz Kostrzewski,
Christopher E Chambers,
Emma Jane Davies,
Antonio Ramos Montoya,
Jacqueline H. L. Fok,
David J. Hughes,
Kristin Fabre,
Matthew P. Wagoner,
John P. Wikswo,
Clay W. Scott
Publication year - 2022
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.3001624
Subject(s) - in vivo , biology , pharmacokinetics , in vitro , pharmacology , cell culture , in vitro toxicology , biochemistry , microbiology and biotechnology , genetics