Open AccessAdvanced human mucosal tissue models are needed to improve preclinical testing of vaccines
Author(s) -
David Komla Kessie,
Thomas Rudel
Publication year - 2021
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.3001462
Subject(s) - preclinical testing , biology , clinical trial , predictability , preclinical research , human use , computational biology , vaccine trial , bioinformatics , microbiology and biotechnology , physics , quantum mechanics
Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.